Neurological and Molecular Basis of Diabetic Neuropathy

Authors

  • Kehinde Alare Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
  • Taiwo Alare Department of Mechanical Engineering, Federal University of Technology, Akure, Ondo State, Nigeria.
  • Tope Odunitan Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.

Keywords:

Diabetic neuropathy, Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH), Demylination.

Abstract

Aims: The aim of the research is to look to the neurological and molecular mechanism of diabetic neuropathy and also suggesting a better way of management. Methods: Critical reviews of the relationship between hyperglycemia in diabetes with polyol pathway, hexose monophosphate shunt and de novo synthesis of sphingolipids and how this relationship could be involved in diabetic neuropathy. Results: The research gave rise to some factor causing diabetic neuropathy such as osmotic stress, oxidative stress, demyelination and are gotten from the method above. Conclusion: This research pointed out decrease NADPH available for de novo synthesis of sphingomyelin as result of increased consumption by polyol pathway and decrease production by hexose monophosphate shunt as the main factor responsible for diabetic neuropathy

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Published

2020-10-28

How to Cite

Kehinde Alare, Taiwo Alare, & Tope Odunitan. (2020). Neurological and Molecular Basis of Diabetic Neuropathy. International Journal of Recent Innovations in Medicine and Clinical Research (ISSN: 2582-1075), 2(4), 75–81. Retrieved from https://ijrimcr.com/index.php/ijrimcr/article/view/70

Issue

Vol. 2 No. 4 (2020): VOLUME 2, ISSUE 4, OCT-DEC-2020

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.